Recombinant Human Cystatin-C (rHuCystatin-C)
英文全名
Recombinant Human Cystatin-C (rHuCystatin-C)英文又名
卵白布局
氨基酸序列
SSPGKPPRLV GGPMDASVEE EGVRRALDFA VGEYNKASND MYHSRALQVV RARKQIVAGV NYFLDVELGR TTCTKTQPNL DNCPFHDQPH LKRKAFCSFQ IYAVPWQGTM TLSKSTCQDAAccession
Gene ID
产物英文概述
来历
份子量
Approximately 13.3 kDa, a single non-glycosylated polypeptide chain containing 120 amino acids.生物活性
No data available.表面
Sterile colorless liquid.配方
Supplied as a 0.2 um filtered solution in 20mM Tris-HCl, pH 8.0, 300 mM NaCl, with 50 % glycerol.内毒素
Less than 0.1 EU/ug of rHuCystatin-C as determined by LAL method.消融申明
贮存前提
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.- 6 months from date of receipt, -20 to -70 °C as supplied.- 3 months, -20 to -70 °C under sterile conditions after opening.参考材料
Cystatin C is a member of family 2 of the Cystatin superfamily. It is involved in processes such as tumor invasion and metastasis, inflammation and some neurological diseases. It inhibits many cysteine proteases such as papain and cathepsins B, H, K, L and S. It is ubiquitous in human tissues and body fluids. A point mutation in the gene coding for the 120 amino acid mature Cystatin C causes a hereditary form of amyloid angiopathy in which the protein variant (Leu68 to Gln) is deposited in the cerebral arteries, leading to fatal cerebral hemorrhage. Cystatin C may have additional clinical applications. For example, it is a good marker for glomerular filtration rate.纯度
> 98 % by SDS-PAGE and HPLC analyses.SDS-PAGE电泳
